Bulbar and pseudobulbar palsy

Overview

• A bulbar palsy is a lower motor neuron lesion of cranial nerves IX, X and XII.
• A pseudobulbar palsy is an upper motor neuron lesion of cranial nerves IX, X and XII.

Causes

Bulbar palsy

• Motor neurone disease
• Syringobulbia
• Guillain-Barre syndrome
• Poliomyelitis
• Subacute menignitis (carcinoma, lymphoma)
• Neurosyphilis
• Brainstem CVA

Pseudobulbar palsy

The commonest cause is bilateral CVAs affecting the internal capsule.

Other causes include:

• Multiple sclerosis
• Motor neurone disease
• High brainstem tumours
• Head injury

Features

Bulbar palsy

The clinical features include:

• Gag reflex – absent
• Tongue – wasted, fasciculations
  “wasted, wrinkled, thrown into folds and increasingly motionless”.
• Palatal movement – absent.
• Jaw jerk – absent or normal
• Speech – nasal
  “indistinct (flaccid dysarthria), lacks modulation and has a nasal twang”
• Emotions – normal
• Other – signs of the underlying cause, e.g. limb fasciculations.

Pseudobulbar palsy

The clinical features include:

• Gag reflex – increased or normal
• Tongue – spastic
  “it cannot be protruded, lies on the floor of the mouth and is small and tight”.
• Palatal movement – absent.
• Jaw jerk – increased
• Speech – spastic: “a monotonous, slurred, high-pitched, ‘Donald Duck’ dysarthria”  that “sounds as if the patient is trying to squeeze out words from tight lips”.
• Emotions – labile
• Other – bilateral upper motor neuron (long tract) limb signs.

References and Links

LITFL

• Neurological Mind Boggler 005 — Pseudobulbar and Bulbar Palsies

CCC Differential Diagnosis Series
NEURO	Anosmia, Ataxia, Blepharospasm, Bulbar and Pseudobulbar palsy, Central Pontine Myelinosis, Cerebellar Disease, Chorea, Cranial nerve lesions, Dementia, Dystonia, Exophthalmos, Eye trauma, Facial twitches, Fixed dilated pupil, Horner syndrome, Loss of vision, Meningism, Movement disorders, Optic disc abnormality, Parkinsonism, Peripheral neuropathy, Radiculopathy, Red eye, Retinal Haemorrhage, Seizures, Sudden severe headache, Tremor, Tunnel vision
RESP	Bronchial breath sounds, Bronchiectasis, High airway pressures, Massive haemoptysis, Sore throat, Tracheal displacement
CVS	Atrial Fibrillation, Bradycardia, Cardiac Failure, Chest Pain, Murmurs, Post-resuscitation syndrome, Pulseless Electrical Activity (PEA), Pulsus Paradoxus, Shock, Supraventricular tachycardia (SVT), Tachycardia, VT and VF, SVC Obstruction
GIT	Abdominal distension, Abdominal mass, Abdominal pain, Asterixis, Dysphagia, Hepatomegaly, Hepatosplenomegaly, Large bowel obstruction, Liver palpation abnormalities, Lower GI haemorrhage, Malabsorption, Medical causes of abdominal pain, Rectal mass, Small bowel obstruction, Upper GI Haemorrhage
GUT	Genital ulcers, Groin lump, Scrotal mass, Urine colour, Urine Odour, Urine transparency,
MSK	Arthritis, Shoulder pain, Wasting of the small muscles of the hand
DERM	Palmar erythema, Serious skin signs in sick patients, Thickened Tethered Skin, Leg ulcers, Skin Tumour, Acanthosis Nigricans
ENDO	Diabetes Insipidus, Diffuse Goitre, Gynaecomastia, Hirsutism, Hypoglycaemia, SIADH, Weight Loss
HAEM	Splenomegaly
PAEDS	Floppy infant
MISC	Anaphylaxis, Autoimmune associated diseases, Clubbing, Parotid Swelling, Splinter haemorrhages, Toxic agents and abnormal vitals, Toxicological causes of cardiac arrest
IMAGING	CHEST: Atelectasis, Hilar adenopathy, Hilar enlargement on CXR, Honeycomb lung, Increased interstitial markings, Mediastinal widening on mobile CXR, Pulmonary fibrosis, Pseudoinfiltrates on CXR, Pulmonary opacities on CXR, ABDO: Gas on abdominal X-ray, Kidney mass, BRAIN: Intracranial calcification, Intracranial structures with contrast, Ventriculomegaly, OTHER: Pseudofracture on X-Ray,
LABS	LOW: Anaemia, Hypocalcaemia, hypochloraemia, Hypomagnesaemia,  HIGH: Bilirubin and Jaundice, Hyperammonaemia, Hypercalcaemia, Hyperchloraemia, Hyperkalaemia, Hypermagnesaemia,  ACID BASE: Acid base disorders, Resp. acidosis, Resp. alkalosis, Creatinine, CRP, Dipstick Urinalysis, Laboratory Urinalysis, Liver function tests (LFTs), Pleural fluid analysis, Urea, Urea Creatinine Ratio, Uric acid, Urinalysis, Urine Electrolytes

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