- A prolonged QT interval is associated with an increased risk of torsade de pointes.
- A rise in heart rate is associated with a shortening of the QT interval and similarly a slowing of the heart rate is associated with a longer QT interval.
- Bazett formula ‘corrects‘ the measured QT interval to a value (QTc) attributable to a heart rate of 60 bpm. Thus providing a QT interval value that a particular patient would theoretically have if their heart rate was 60 beats/min
1891 – Augustus Desiré Waller provided a series of values for the duration of mechanical systole with different heart rates. He demonstrated that the period of mechanical contraction (systole) was shortened at faster heart rates
1919 – Lombard WP and Cope OM recorded measurements of the carotid pulse in patients standing, lying and sitting and following exercise to derive an equation for measuring the duration of systole.
1920 – Bazett used Waller’s 1891 data to create a formula which could estimate/calculate the duration of systole with varying pulse rates. He then reviewed electrical and mechanical data from Weitz, Wiggars, Lewis, Buchanan, Kraus and Nicholai to confirm his calculations. He concluded:
‘Waller gives values for the duration of mechanical systole with different heart rates, and it will be seen that almost exactly similar figures are obtained by calculation from the formula Systole = k √ cycle, where K has a value of 0.343.‘
‘The (Lombard, Cope 1919) results are confirmed by the figures here reported, in spite of the difference in the method employed, and I had independently arrived at the same relationship of systole to the square root of the cycle before the publication of their results‘
‘The duration of the ventricular complex in an electrocardiogram is in the normal heart a function of the pulse rate, and may be determined by the formula: Systole = k √ cycle. The normal value for k is 0.37 for men and 0.40 for women.‘
1947 – Taran and Szilagyi related QT prolongation to acute rheumatic carditis in children. In doing so, they updated Bazett’s original formula:
- Augustus Desiré Waller (1856-1922)
- Henry Cuthbert Bazett (1885 – 1950)
- Louis Sigurd Fridericia (1881-1947)
- Taran and Szilagyi corrected QT interval
- Bazett formula modified by Taran and Szilagyi
- Bazett QTc calculation unreliably identifies patients with prolonged QTc interval [Charbit 2006]
- Bazett HC. An analysis of the time-relations of electrocardiograms. Heart. 1920;7:353-70.
- Waller AD. A demonstration on man of electromotive changes accompanying the heart’s beat. Journal of Physiology 1887;8:229-34. [First ECG in Man]
- Waller AD. Introduction to Human Physiology. Longman, Green; 1891. pp 53.
- Lombard WP, Cope OM. Effect of pulse rate on the length of systoles and diastoles in the normal human heart in the standing position. American journal of physiology, 1919 p139-140
- Taran LM, Szilagyi N. The duration of the electrical systole, Q-T, in acute rheumatic carditis in children. Am Heart J. 1947 Jan;33(1):14-26. [PMID 20280672]
- Besterman E, Creese R. Waller–pioneer of electrocardiography. Br Heart J. 1979 Jul;42(1):61-4. [PMC482113]
- Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis. 1988 Sep-Oct;31(2):115-72. [PMID 3047813]
- Corrected QT Interval (QTc) MDCalc.com
- Luo S, Michler K, Johnston P, Macfarlane PW. A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs. J Electrocardiol. 2004;37 Suppl:81-90. [PMID 15534815]
- Charbit B, Samain E, Merckx P, Funck-Brentano C. QT interval measurement: evaluation of automatic QTc measurement and new simple method to calculate and interpret corrected QT interval. Anesthesiology. 2006 Feb;104(2):255-60. [PMID 16436843]
- Indik JH, Pearson EC, Fried K, Woosley RL. Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval. Heart Rhythm. 2006 Sep;3(9):1003-7 [PMID 16945790]