Folate Deficiency
Folate Deficiency: 500-20,000 mcg stored in body; required 50-100mcg/day; required for DNA, RNA and protein synthesis (purine, thymidine and amino acid synthesis)
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Glucose Control in the Critically Ill
Routine management in ICU involves avoiding complications of hyperglycaemia (infections) and hypoglycaemia (arrhythmias, neurological damage, cardiac events). Traditional goals have varied
Immunonutrition
Immunonutrition involves feeding (enteral or TPN) enriched with various nutrients (arginine, glutamine, omega-3-fatty acids, nucleotides and anti-oxidants: copper, selenium, zinc, vitamins B, C and E) to improve immune responses and modulate inflammatory responses
Indirect Calorimetry and Metabolic Cart
Indirect calorimetry is a technique that measures inspired and expired gas flows, volumes and concentrations of O2 and CO2. The equipment used is also known as a metabolic cart
Nasogastric tube vs PEG vs Jejunostomy
Nasogastric tube vs Percutaneous endoscopic gastrostomy (PEG) vs Jejunostomy
Intolerance to Enteral Nutrition
OVERVIEW CAUSES Patient Mechanical Drugs ASSESSMENT History Examination Investigations MANAGEMENT General approach Approach to gastric residual volumes >500mL q6h References and Links LITFL Journal articles
Nutrition Literature Summaries
summaries of key studies from the intensive care nutrition literature
Nutritional Assessment in the Critically Ill
Nutritional Assessment in Critical Illness: poor nutritional state is a common feature of critically ill patients, either pre-existing or as a result of the illness
Overfeeding
In the 1980s, the concept of parenteral hyperalimentation or hypercaloric feeding was dominant. This was stopped due to the sequelae, which limit attempts to rapidly correct malnutrition. Some early studies suggesting harm from early feeding were actually showing the effects of overfeeding
Periprocedural Fasting
Periprocedural fasting is widely performed with little evidence base. NBM = nil by mouth; NPO = nil per oral
Prokinetics
Prokinetics are agents that increase gastrointestinal motility. Gastroparesis common -> increased gastric residual volumes -> GORD, aspiration risk and inability to meet nutrition targets. Theoretically, an increase in gastric motility helps in establishing target enteral feeds early in critically ill patients, which improves outcome
Refeeding Syndrome
Refeeding Syndrome = a group of clinical findings that occur in severely malnourished individuals undergoing nutritional support.