Category Haematology
CCC Critical Care compendium 340

von Willebrand Disease

von Willebrand Disease: commonest inherited coagulation disorder (autosomal dominant); protein involved in (1) platelet adhesion and (2) carriage of factor VIII; leads to: factor VIII deficiency, abnormal platelet adhesiveness and abnormal vascular endothelium
CCC Critical Care compendium 340

VTE Prophylaxis

Venous thromboembolism (VTE) may contribute to up to 12% of deaths in ICU and is the No.1 preventable cause of hospital death; asymptomatic events range from 10-80% in various medical and surgical groups
CCC Critical Care compendium 340

Porphyria

OVERVIEW Porphyria = group of disorders where patients have a inability to synthesis Hb resulting in an accumulation of precursors oxidised to porphyrins hepatic and erythropoietic varieties 3 hepatic forms that effect are affected by anaesthesia (1) AIP – acute…

CCC Critical Care compendium 340

Phlegmasia Cerulea Dolens

Phlegmasia Cerulea Dolens refers to congestion and cyanosis of a limb due to massive venous thrombosis; part of a spectrum with phlegmasia alba dolens and venous gangrene
CCC Critical Care compendium 340

Lupus Anticoagulants

OVERVIEW Lupus Anticoagulants antibodies that block phospholipids surfaces important for coagulation increase APTT prolonged APTT does not correct with a 1:1 mix of normal platelet-free plasma correction of clotting time after addition of excess phospholipids confirms the presence of LA…

CCC Critical Care compendium 340

Haemolytic anaemia

Reviewed and revised 27 October 2016 OVERVIEW Definition Haemolytic anaemia is anemia due to shortened survival of red blood cells (RBCs) in the circulation Normal RBC lifespan is about 120 days, therefore it is useful to think of hemolytic anemia…