FEAST and Paediatric Fluid Resuscitation
FEAST = Fluid Expansion As Supportive Therapy. Trial was a landmark study investigating the effects of fluid boluses in the resuscitation of febrile children with evidence of poor perfusion
Category Medical Specialty
Steroids and Septic Shock Literature Summaries
Bone R.C. et al (1987) “A controlled clinical trial of high dose methylprednisolone in the treatment of severe sepsis and septic shock” NEJM, 317:653-658 PMID 3306374 RCT n = 382 with sepsis and organ dysfunction methylprednisolone (30mg/kg) vs placebo-> no…
Smoke inhalation
Smoke is a complicated heterogeneous mixture of potentially toxic gases, chemical fumes, asphyxiants and particulate debris. Smoke inhalation is commonly seen in patients with burns as a result of fire; it is associated with high morbidity and mortality
Central Diabetes Insipidus
Diabetes insipidus (DI) is a condition caused by loss of the effect of antidiuretic hormone on the collecting ducts of the kidneys, resulting in loss of free water.
Lund Concept for Traumatic Brain injury
A 'volume-targeted' approach to the management of TBI developed by a Swedish group (not ABBA), based on physiological volume regulation of the intracranial compartments. The Lund concept contradicts the prevailing strategem of titrating CPP to match ICP in TBI
Temperature and Traumatic Brain Injury
Temperature and TBI. Induced hypothermia has been used for years to reduced cerebral metabolic rate; manipulation of temperature has been shown to effect certain types of brain injury (therapeutic hypothermia in out-of-hospital cardiac arrest).
Polyuria and Traumatic Brain Injury
polyuria following TBI is common; multiple causes, some of which imply a poor prognosis. Goal is to identify and treat the cause and any complications
Brain Impact Apnoea
Brain impact apneoa is an under-appreciated cause of morbidity and mortality in traumatic brain injury (TBI)
Minimum Inhibitory Concentration
Minimum Inhibitory Concentration (MIC) is lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism following overnight incubation, usually reported as mg/L
Limitations of CT in Traumatic Brain Injury
Limitations of CT head scan in Traumatic Brain Injury (TBI)
Antibiotic Dosing in Renal Replacement Therapy
Little published data to guide dosing of antibiotics in RRT and the critically ill. therefore we must use first principles and utilize therapeutic drug monitoring if available.
Cerebral Perfusion Pressure in TBI
Cerebral Perfusion Pressure (CPP) in Traumatic brain injury (TBI). Cerebral Perfusion Pressure (CPP) = MAP – ICP or CVP (whichever is highest)