Category Medical Specialty
CCC Critical Care compendium 340

Evidence-based Toxicology

Much of what we do in toxicology is because we think it works, not because we know it works. Clinical toxicology has traditionally been based on animal studies, case reports and case series based on clinical observation rather than clinical trials

CCC Critical Care compendium 340

Iron Overdose

Iron overdose can have local gastrointestinal effects as well as characteristic systemic toxicity (metabolic acidosis, liver failure, shock and multi-organ failure). Risk assessment is based on the amount of elemental iron ingested

CCC Critical Care compendium 340

Plant Toxicity

Severe toxicity from plants is rare in humans; risk assessment is often difficult - plant identification may be difficult; - toxin quantification may be impossible

CCC Critical Care compendium 340

Antibiotic Timing

The mantra for timing of antibiotics for serious infections is 'hit hard, early and appropriately'. Despite the strong biological plausibility of a need for early antibiotics in patients with serious bacterial infections the importance of antibiotic timing is controversial