Drug Withdrawal States in ICU
Drug withdrawal in ICU is more common than generally appreciated.
Category Toxicology
Extracorporeal Elimination in Toxicology
Extracorporeal Elimination recommended for the following intoxications: methotrexate, procanamide, lithium, metformin, ethanol, methanol, ethylene glycol, salicylates, theophylline, sodium valproate.
Gastrointestinal Decontamination
The role for digestive tract decontamination depends on: severity of poisoning; time from ingestion; risk of intervention
Cyanide Poisoning
Cyanide is a potentially lethal toxic agent that can be found in liquid and gaseous form. First discovered in 1786 by Scheele, who extracted it from the dye Prussian blue - and promptly died from exposure to the vapours
Selective Digestive Decontamination
Selective Digestive Decontamination (SDD) is a prophylactic strategy to prevent or minimize nosocomial endogenous and exogenous infections in critically ill patients
Isoniazid toxicity
Isoniazid toxicity, like other hydrazines, primarily cause life-threatening seizures and lactic acidosis through depletion of vitamin B6. The antidote is pyridoxine
Cocaine Toxicity and Obstetrics
Cocaine Toxicity and Obstetrics:
Toxic Alcohol Ingestion
Highlights and pearls on toxic alcohol ingestion from the EBMedicine article, "Toxic Alcohols: Not Always A Clear-Cut Diagnosis"
Tricyclic Antidepressant Toxicity
Tricyclic Antidepressants (TCA) are weak bases (pKa 8.5) that can cause life-threatening sodium channel toxicity
Mushroom Toxicity
Severe toxicity from mushrooms is rare in humans; most symptomatic presentations are a self-limiting gastroenteritis requiring supportive care only; lethal hepatotoxicity from Amanita mushrooms must be excluded
Carbon Monoxide Poisoning
Carbon monoxide (CO) is a colourless, odourless gas produced by incomplete combustion of carbonaceous material. CO poisoning may be acute or chronic
Smoke inhalation
Smoke is a complicated heterogeneous mixture of potentially toxic gases, chemical fumes, asphyxiants and particulate debris. Smoke inhalation is commonly seen in patients with burns as a result of fire; it is associated with high morbidity and mortality