Competitively blocks the formation of toxic metabolites in toxic alcohol ingestion by having a higher affinity for the enzyme Alcohol Dehydrogenase (ADH). Its chief application is in methanol and ethylene glycol ingestion, although it has been used with other toxic alcohols. Ethanol is now regarded as the second choice antidote in those countries with access to the specific ADH blocker, fomepizole.
Desferrioxamine is an effective iron chelator that is used to treat systemic iron toxicity or prevent the development of systemic toxicity following acute iron overdose. It should ideally be given before iron moves intracellularly and systemic toxicity develops.
This rarely used intramuscular chelator is the most toxic of all chelating agents, and is reserved for the treatment of severe poisoning from lead, inorganic arsenic and mercury, if possible EDTA or Succimer should be used instead.
Ciguatera Poisoning: A bizarre poisoning syndrome with acute and sometimes severe neurological and gastrointestinal symptoms caused by eating tropical reef fish that have accumulated ciguatoxin from the dinoflagellate Gambierdiscus toxicus; most common cause of fish poisoning worldwide.
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