Paracetamol is a hard overdose to understand. There I said it. I’m no longer going to feel bad when I have to sit down and work this one out.
Amisulpride is an atypical antipsychotic in low doses will causes and anticholinergic effect but at higher doses prolongs the QT interval with cases of torsades de pointes noted.
Normally used to ameliorate dyskinesia from antipsychotics but has been used for recreational purposes. Benztropine is a potent anticholingeric in overdose. You may also use it yourself as an antidote for an acute dystonic reaction.
Lithium is commonly used to treat bipolar, for your toxicology encounter it will come in two varieties, either an acute overdose or chronic toxicity and it is important to distinguish the two (examiners love this question).
Clozapine is an atypical antipsychotic, due to its restricted use an acute overdose is a rare event but clinicians should be aware that coma can occur and management is with supportive care. In chronic toxicity agranulocytosis and myocarditis can occur, these are not features of an acute poisoning but monitored in patients with long term therapeutic use.
Olanzapine is a second generation atypical antipsychotic. Widely used in Australasia and therefore a fairly common presentation to the emergency department. Olanzapine like queitiapine has a predictable dose-dependent CNS depression.
Quetiapine is a second generation atypical antipsychotic. Widely used in Australasia and therefore a fairly common presentation to the emergency department. Quetiapine is associated with a predictable dose-dependent CNS depression.
Phenothiazines and butyrophenones are the antipsychotic (neuroleptic) agents. Commonly used agents are chlorpromazine, prochlorperazine, droperidol and haloperidol. Other unfamiliar agents include fluphenazine, Pericyazine, Pipothiazine and Trifluoperazine