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Category Toxicants
Toxicology-Library-Toxicant-Drug-340-256

Beta-blocker toxicity

Beta blocker overdoses can be relatively benign but a couple can causes serious cardiotoxicity and even death if not managed aggressively.
Toxicology-Library-Toxicant-Drug-340-256

Clonidine toxicity

Clonidine has a vast array of uses including anxiety, ADHD, hypertension, withdrawal (opitates, alcohol and smoking), migraines, menopausal flushing, diarrhoea and finally pain. It causes the classic triad of drowsiness, miosis and bradycardia in overdose.
Toxicology-Library-Toxicant-Drug-340-256

Chloroquine and Hydroxychloroquine

Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences.
Toxicology-Library-Toxicant-Drug-340-256

Mirtazapine toxicity

Mirtazapine is a novel tetracyclic antidepressant, in overdose it frequently has a benign course with mild CNS depression and tachycardia.
Toxicology-Library-Toxicant-Drug-340-256

SNRI toxicity

SNRIs or Selective serotonin and noradrenaline reuptake inhibitors are mainly in the form of venlafaxine and desvenlafaxine. Venlafaxine in overdose can be potentially life threatening, causing seizures and cardiotoxicity.
Toxicology-Library-Toxicant-Drug-340-256

SSRI toxicity

SSRIs or Selective serotonin reuptake inhibitors are common in overdose and usually follow a benign course. Serotonin toxicity occurs in a minority but is more common with co-ingestant agents with serotonergic action
Toxicology-Library-Toxicant-Drug-340-256

TCA toxicity

This is your one stop page for TCA overdose. Find out how to manage the acute overdose and the potential complications. We have also covered the basic TCA pharmacology and a tutorial about sodium channel blockade and the ECG, find out why the QRS will widen.
Toxicology-Library-Toxicant-Drug-340-256

Sedating Antihistamines

The sedating antihistamines include brompheniramine, chlorpheniramine, cyproheptadine, dexchlorpheniramine, dimenhydrinate, diphenhydramine, doxylamine, pheniramine and promethazine
Toxicology-Library-Toxicant-Drug-340-256

Non-sedating Antihistamines

The non-sedating antihistamines include cetirizine, desloratadine, fexofenadine, levocetirizine and loratadine. In overdose they cause mild CNS depression, in therapeutic and supra therapeutic doses they have been associated with QT prolongation.
Toxicology-Library-Toxicant-Drug-340-256

Bupropion toxicity

Bupropion is an antidepressant mainly used now for nicotine suppression. It comes as an extended release preparation 150 mg in Australian and New Zealand. In overdose it can cause seizures and cardiotoxicity however, good supportive care usually prevents any adverse outcome.
Toxicology-Library-Toxicant-Drug-340-256

Valproic Acid

Valproic acid (sodium valproate) in overdose results in CNS depression and large overdoses can result in multi-system organ failure and death. Chronic toxicity can cause life threatening hyperammonia and hepatotoxicity.
Toxicology-Library-Toxicant-Drug-340-256

MAOI toxicity

Monoamine Oxidase inhibitors (MAOIs) come in different varieties and there is a little more to remember than just the interaction with cheese. The irreversible non-selective (MAO-A+B) are notorious for causing lethal serotonin toxicity in overdose, these include Phenelzine and Tranylcypromine.