Kayser-Fleischer Ring

Description

• What is the actual eponymous medical sign/syndrome/repair/classification…

History

1902 Kayser

1903 – Fleischer description in the same journal, a year after Kayser. His contribution went beyond that of Kayser, he recognised that the ring was a marker for a particular neuropsychiatric disorder associated with cirrhosis. However his breakthrough was overshadowed by the work of Kinnier Wilson…

1934 Both Kayser and Fleischer postulated silver deposition as the cause. First published report of copper being the causative agent was in 1934 by Dr. Werner Gerlach and Willhelm Rohrschneider.

Associated Persons

• Bernard Kayser (1869 – 1954)
• Bruno Fleischer (1874 – 1965)
• Kinnier Wilson (1878-1937)

Alternative names

• Name
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Controversies

• Kayser-Fleischer Ring – not to be confused with Fleischer Ring (associated with keratoconus and described in 1906)

References

• Kayser B. Ueber einen Fall von angeborener grünlicher Verfärbung der Cornea. Klinische Monatsblatter für Augenheilkunde. 1902;40(2):22-25 [Kayser-Fleischer Ring]
• Fleischer B. Zwei weiterer Falle von grunlicher Verfarbung der Kornea. Klinische Monatsblätter für Augenheilkunde 1903; 41: 489-91 [Kayser-Fleischer Ring]
• Wilson SAK. Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver. Brain 1912; 34(4): 295-507. [Wilson disease]
• Gerlach W, Rohrschneider W. Besteht das Pigment des Kayser-Fleischerschen Hornhautringes aus Silber? Klinische Wochenschrift. 1934;13(2):48-49