Luigi Luciani (1840 – 1919) was an Italian neuroscientist.
Luciani was an important contributor to the basic understanding of cardiac automacity, cerebellar function, and the fasting response
Widely regarded as as an outstanding teacher and cardiovascular historian
Responsible for recording a five-volume comprehensive chronicle on human physiology in the early 1900’s – Fisiologia dell’uomo – published in several languages and continued through five editions
- Born 23 November 1840 Ascoli Piceno, Italy
- 1862 – Medical school, University of Bologna
- 1864 – published his first paper as a second year medical student, then transferred to the University of Naples for health reasons
- 1865 – returned to the University of Bologna to avoid a cholera epidemic in Naples
- 1868 – completed medical school with distinction, thenceforth he stayed as an assistant, then as the full-time Director of Physiology
- 1872 – Following two prominent publications, he worked with Carl Ludwig in his physiology laboratory in Leipzig.
- 1873 – Demonstrated ‘cardiac group beating‘ using an isolated frog heart, as later referenced by Wenckebach
- 1873 – In Leipzig, founded a Physiology Society in order to weekly discuss important publications
- 1875 – Professor of pathology, University of Parma
- 1880-1882 – Chairman of Physiology, University of Sienna
- 1882-1893 – Chairman of Physiology, University of Florence
- 1893-1917 – Chairman of Physiology, University of Rome
- Also served as a member of the Superior Council of Education, as a senator, and as rector of the University of Rome
- 1900 – His 25 years as a professor was celebrated
- Died 23 June 1919 in Rome, of a urinary tract infection
Key Medical Attributions
1873 whilst studying frogs hearts in Carl Ludwig’s laboratory in Leipzig – Luciani demonstrated cardiac group beating (which he named periodic rhythm) and recorded 2nd degree AV blocks
1899, Karel Wenckebach credited Luciani with his discovery referring to the phenomena as ‘Luciani periods‘. With the advent of the ECG, this form of group beating became known as ‘Wenckebach periodicity‘, the ‘Wenckebach phenomena‘ and later as ‘Mobitz type I atrioventricular block‘ (1924)
Luciani distinguished three stages of starvation in man: hunger; physiological inanition; and pathological inanition. Luciani succeeded in keeping dogs alive after total excision of the cerebellum, and initiated the modern study of cerebellar function
- Luciani periods
- Second-degree Atrioventricular block – Mobitz Classification; Mobitz type I (Wenckebach) and Mobitz type II (Hay)
- Luciani is remembered for his research on the cerebellum, during which he worked at an insane asylum. He also successfully removed the cerebellum of a dog and a monkey, keeping decerebellated animal subjects alive for as much as one year
- Extensive research on the physiology of fasting, studying professional exhibition fasters throughout Europe
‘I have always worked because work itself has given me the greatest pleasure in my life’
‘I do not deserve any credit, I only followed my basic instincts’
‘Out of a sentiment of gratitude and justice that will never be extinguished I recognize Professor Ludwig as my true mentor’
- Luciani L. Dell’attività della diastole cardiaca [Cardiac diastolic activity] Fava e Garagnani. 1871.
- Luciani L. Eine periodische Function des isolirten Froschherzens [A periodic function of the isolated frog heart]. Berichte über die Verhandlungen der Königlich Sächsischen Gesellschaft der Wissenschaften zu Leipzig. 1873;25:11–94.
- Luciani L, Seppilli G. Le localizzazioni funzionali del cervello. Napoli 1885
- Luciani L. Die Functions-Localization auf der Grosshirnrinde. Leipzig 1886
- Luciani L. Fisiologia del digiuno : studi sull’uomo. Firenze, Sucessori Le Monnier 1889
- Luciani L, Moleschott J. Das Hunger: Studien und Experimente am Menschen. Hamburg: Leopold Voss 1890;230
- Luciani L. Fisiologia dell’uomo [Human physiology] Società EditriceLibraria. 1908.
- Luciani L. Human physiology. Vol I – Circulation and Respiration. Macmillan and Co. 1911. [Cardiac Group Beating pp 285-337]
- Luciani L. Human physiology. Vol II – Internal secretion, digestion, excretion. The skin. Macmillan and Co. 1913.
- Luciani L. Human physiology. Vol III – Muscular and Nervous Systems. Macmillan and Co. 1915.
- Luciani L. Human physiology. Vol IV – The Sense Organs. Macmillan and Co. 1917.
- Luciani L. Human physiology. Vol V – Metabolism, temperature and reproduction. Macmillan and Co. 1918.
- Upshaw CB Jr, Silverman ME. Luigi Luciani and the earliest graphic demonstration of Wenckebach periodicity. Circulation. 2000 Jun 6;101(22):2662-8. [PMID 10840021]
- Silverman ME, Upshaw CB Jr, Lange HW. Woldemar Mobitz and His 1924 Classification of Second-Degree Atrioventricular Block. Circulation. 2004 Aug 31;110(9):1162-7. [PMID 15339865]
- Fano G. In Memoria di Luigi Luciani. Archivio Di Fisiologia. 1921;19:319-349
- Cadogan M. History of the Electrocardiogram. LITFL
- Cadogan M. History of Second-degree Atrioventricular block. LITFL
the person behind the name