An adaptive clinical trial involves a study design in which key characteristics are adjusted while enrollment in the trial is ongoing using prospectively defined decision rules and in response to information arising from the data accumulating in the trial
Chi-square Test is used to compare categorical data; often displayed in contingency table with rows (x) and columns (y)
Obesity has multiple pathophysiological effects and leads to numerous multi-system complications
Bariatric Patient Hot Case
Reviewed and revised 24 May 2014 OVERVIEW MECHANISM OF ACTION TOXICOKINETICS RISK ASSESSMENT CLINICAL FEATURES Effects include: Complications INVESTIGATIONS (Guided by clinical assessment) Laboratory tests MANAGEMENT Resuscitation Supportive care and monitoring Decontamination Disposition References and Links Journal articles
Renal replacement therapy: Fluid Management
Enhanced elimination techniques serve to increase the rate of removal of an agent from the body with the aim of reducing the severity and duration of clinical intoxication.
Ethanol (ethyl alcohol) is an aliphatic alcohol, C2H5OH. The primary effect of ethanol is CNS depression, which is additive with other CNS depressants
High-dose Insulin Euglycaemic Therapy (HIET) is primarily used in the therapy of severe calcium channel blocker toxicity. HIET can also be used for severe beta blocker toxicity and potentially other toxicities/ presentations requiring inotropic support
A 76-year-old female is admitted to the ICU following elective aortic and mitral valve replacement. Trans- oesophageal echo assessment at the end of surgery showed an ejection fraction of 20%. Her preoperative creatinine was 340 μmol/L. Total bypass time was 240 minutes.
Question A 27-year-old female presents to the Emergency Department after a collapse at work that was followed by a brief tonic-clonic seizure. She is 30 weeks pregnant with no previous pregnancies or other significant medical history. She currently localises bilaterally…
Question A health care worker, recently returned from West Africa, presents to the Emergency Department with fevers, vomiting and diarrhoea. Her vital signs are normal on presentation. Blood tests have not been taken, and venous access has not been established.Your…