CCC Critical Care compendium 340
Co-trimoxazole

Co-trimoxazole: 2 antibiotics (sulfamethoxazole and trimethoprim) -> blocks two consecutive steps in the biosythesis of nucleic acids and proteins essential to bacteria.

CCC Critical Care compendium 340
AAA Repair Patient Hot Case

GENERAL APPROACH Emergency or Elective End-organ damage Complications– brain injury– spinal cord ischaemia– ileus– MI– lower limb ischaemia– compartment syndromes– renal injury INTRODUCTION CUBICLE dialysis INFUSIONS vasoactives fluid boluses sedation analgesia transpyloric feeding: ileus, ischaemia TPN VENTILATOR mode level of…

CCC Critical Care compendium 340
Clopidogrel

Clopidogrel: anti-platelet agent; inhibition of the ADP platelet receptor and subsequent ADP-mediated activation of the glycoprotein IIb/IIIa complex -> inhibits platelet aggregation

CCC Critical Care compendium 340
COX II Inhibitors

Selective COX-2 inhibitors developed to try and inhibit prostacyclin synthesis by the COX-2 isoenzyme induced at sites of inflammation without affecting the action of the constitutively active COX-1 isoenzyme found in gastic mucosa, platelets & kidney.

CCC Critical Care compendium 1200
Dipyridamole

Dipyridamole: anti-platelet + vasodilator. Potentiates the effect of prostacyclin or by inhibiting phosphodiesterase enzyme activity -> increase intracellular cAMP; inhibits cellular uptake of adenosine -> more available to act on coronary vessels -> vasodilation

CCC Critical Care compendium 340
Post Operative Confusion

OVERVIEW RISK FACTORS CAUSES Anaesthetic Surgical INVESTIGATIONS MANAGEMENT Resuscitate Electrolytes and Acid-base Specific Therapy Underlying Cause References and Links