Pancoast Syndrome


Pancoast Syndrome occurs secondary to local compression of brachial plexus and sympathetic chain by superior (pulmonary) sulcus tumors. Associated tumors are usually non-small cell lung cancer (NSCLC) and interchangeably referred to as Pancoast Tumours.

Syndrome consists of:

  • Shoulder pain: initially localised to shoulder and vertebral border of scapula)
  • Radicular pain C8-T2: Progressive ulna nerve distribution pain and muscular atrophy
  • Horner syndrome: present in 25% of presentations of Superior sulcus tumors. Extension of neoplastic invasion/compression to involve sympathetic chain and stellate ganglion

Example Cases: CXR Case 064CXR Case 069Befuddler 025

History of Pancoast Syndrome

1838 – British surgeon Edward Selleck Hare (1812-1838) described the case of a man who had died of a tumour on his neck. He had for some time before death exhibited marked constriction of the left pupil and drooping of the Levator palpebrae sutperioris. Hare was the first clinical observer to record the existence of what is now termed “Horner syndrome” in association with a cervical lesion.

1912 – Publio Ciuffini, published a case of primary cancer of the apex of the right lung. He drew the clinicians’ attention to a complex of symptoms which he believed to be characteristic. Symptoms consisted of paresis, paraesthesia, and pain in the ipsilateral arm due to compression of the brachial plexus; ipsilateral ptosis, enophthalmos and miosis; and finally compression of the subclavian artery and vein.

Imponenti furono anche in questo paziente i fenomeni di compressione , esercitati sugli organi vicini: primo a risentire gli effetti di essa fu il plesso brachiale dello stesso lato, a cui seguì, dopo molto tempo, la paralisi unilaterale del ricorrente, la quale in seguito divenne bilaterale, rendendo completamente afono il malato. Ad essa si unirono, un mese prima della fine, gli effetti della lesione della 8th radice cervicale e della l” dorsale, la quale ebbe la sua espressione in quel ristringimento della rima palpebrale destra, in quel l’enoftalmo, nella miosi della pupilla, nella mancanza del riflesso al dolore.

Ciuffini P. Sul cancro primitivo del polmone. 1912

The compression phenomena exerted on nearby organs was impressive in this patient: the first to show the effects was the brachial plexus of the same side, followed, after a long time, by the unilateral paralysis of the recurrent laryngeal nerve, which later became bilateral, making the patient completely mute. It was joined, a month before the end, by the effects of the lesion of the 8th cervical root and of the 1st dorsal, clinically manifest with right eye ptosis, enophthalmos, miosis, and lack of pain reflex.

Ciuffini P. Sul cancro primitivo del polmone. 1912

1924Henry Khunrath Pancoast (1875-1939) described three cases of localised apical lung tumors with neurological findings

Case 1: A man, aged 52, was admitted to the University Hospital early in September, 1921. His chief complaint was intense burning pain, high in the left axilla and extending down the arm, worse at night and keeping him awake. It was then of eleven months’ duration, at first intermittent and later continuous; limited to the shoulder girdle at first, but later referred down the arm to the elbow, and for the last two months to the wrist, during which time there was an associated muscular twitching, increasing weakness of the grip and muscular wasting of the hand.

On admission, there was noted a contracted left pupil, enophthalmos and narrowing of the palpebral fissure.

Pancoast 1924
Pancoast 1924 case 1
Case 1: “…we discovered a shadow in the extreme left apex and destruction of the posterior portions of the left second and third ribs and adjacent corresponding transverse processes” Pancoast 1924
Pancoast 1932 Case 7

Fig. 3 (case 7).—Roentgenogram of the chest, showing the circumscribed apical shadow. Note the upper arrows pointing to the second rib and to the head and neck of the first rib, both of which are intact. Pancoast 1932
Pancoast 1924 Case 10
Fig 10: The appearances due to sympathetic paralysis are well illustrated in a case of lymphosarcoma of the neck with the larger mass on the left side. The patient has pain referred down the left arm and in the third, fourth and fifth fingers, and loss of tactile and pain sensations on the inner side of the right forearm; wrist extension is weak, and there is no grip in the hand. There is very noticeable ptosis of the left lid, contracted pupil and a suggestion of hemiatrophy of the face. Sweating occurs only on the right or opposite side of the face. Pancoast 1924

Associated Persons

Alternative names
  • Superior Sulcus Tumour; Pulmonary Sulcus Tumor
  • Pancoast’s Tumour; Pancoast’s disease
  • Tobías syndrome
  • Ciuffini-Pancoast-Tobías syndrome; Ciuffini-Pancoast syndrome


Original articles

Review articles



the names behind the name

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.