Tag Acetaminophen
Toxicology Library Tox Tutes 340

Paracetamol Update

Paracetamol / Acetaminophen Update. Dr Angela Chiew – Australian Clinical Toxicologist and Emergency Staff Specialist

Paracetamol toxicity

Paracetamol is a hard overdose to understand. There I said it. I'm no longer going to feel bad when I have to sit down and work this one out.
Toxicology-Library-Tox-library-LITFL 340

Buckley on Paracetamol: More Than Meets The Eye

Clinical Toxicologist Nicholas Buckley is one of the biggest brains in the business. In his talk at SMACC he showed us how much there is to know about something so seemingly simple in ‘Paracetamol: More than meets the Eye’. This is a…

Toxicology-Conundrum-340 256

Paracetamol…too much, too often?

You are called by a doctor in a remote hospital asking for advice. The doctor is concerned about the risk of hepatotoxicity from repeated supratherapeutic ingestion (RSI) of paracetamol in the following patient:
CCC Critical Care compendium 340

Acute Paracetamol Toxicity

Acute Paracetamol Toxicity: following overdose glucuronidation and sulphation pathways are rapidly saturated -> increased metabolism to NAPQI (N-acetyl-P-benzoquineimine); glutathione is required to inactivate NAPQI and when levels depleted -> hepatocellular death takes place
CCC Critical Care compendium 340


Paracetamol (acetaminophen): simple analgesic and antipyretic - not an NSAID as it lacks significant anti-inflammatory effects