Funtabulously Frivolous Friday Five 322 - Just when you thought your brain could unwind the medical trivia FFFF
ACEM Primary Pharmacology of Sotalol: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
ACEM Primary Pharmacology of Propranolol: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
ACEM Primary Pharmacology of Metoprolol: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
Beta blocker overdoses can be relatively benign but a couple can causes serious cardiotoxicity and even death if not managed aggressively.
The toxico-mythology of 'unopposed alpha stimulation' and the contra-indication of beta-blockers in the treatment of cocaine, amphetamine and other stimulant toxicity. Down with dogma!
aka Toxicology Conundrum 044 A 27-year old female weighing 60kg presents to ED approximately one hour after swallowing 70 x 40mg propranolol tablets (= 2.8 grams) with suicidal intent. At the time of assessment she is drowsy (GCS 13) with…
Catecholamine excess, or 'sympathetic overload', may be harmful in critically ill patients, including those with septic shock. Catacholamine excess is associated with specific conditions such as Takotsubo cardiomyopathy
Sotalol: anti-arrhythmic; low doses = non-selective beta receptor antagonist; high doses = prolongs action potential
The use of Beta-blockers in perioperative medicine has been an issue of intense research in Anaesthesia. Patients that are believed to benefit from beta-blockers are those with risk factors for ischaemic heart disease (HT, DM, hypercholesterolaemia, previous MI, angina, controlled heart failure)
Elderly patient with accidental overdose of sotalol. Describe and interpret this ECG. LITFL Top 100 ECG. QT prolongation
A review of the ECG changes seen in beta-blocker and calcium-channel blocker poisonings, including propranolol and sotalol, with example ECGs.