Pharm 101: Digoxin
ACEM Primary Pharmacology of Digoxin: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
CLASS anti-arrhythmic (cardiac glycoside) MECHANISM OF ACTION inotropic effect increased automaticity negative dromotropy (slowing of AV conduction) increased vagal tone DIRECT:inhibition of Na/K ATPase on the cell surface-> increased intracellular Na+ and increased extracellular K+-> increased intracellular Ca2+ due to Na+/Ca2+ antiporter->…
the case. 87 year old female presents to your ED following an intentional overdose. She tells you that approximately 4 hours ago she ingested ‘most of [her] digoxin tablets’ that she bought earlier in the afternoon.