Fomepizole
Fomepizole is an alcohol dehydrogenase inhibitor used in management of methanol and ethylene glycol poisoning. It is not currently available in either Australia or New Zealand.
Month February 2019
Folinic Acid
Folinic acid is the active form of folic acid. It is routinely used for “folinic acid rescue therapy” following administration of high-doses of parenteral methotrexate in oncologic practice.
Flumazenil
Flumazenil is a competitive benzodiazepine antagonist with a limited role in the management of benzodiazepine poisoning. Usually to reverse procedural sedation, accidental paediatric ingestion with compromise, and rarely to help make a diagnosis of benzodiazepine overdose or if a patient's airway is compromised without quick access to intubation equipment
Ethanol
Competitively blocks the formation of toxic metabolites in toxic alcohol ingestion by having a higher affinity for the enzyme Alcohol Dehydrogenase (ADH). Its chief application is in methanol and ethylene glycol ingestion, although it has been used with other toxic alcohols. Ethanol is now regarded as the second choice antidote in those countries with access to the specific ADH blocker, fomepizole.
Benztropine
Benztropine is the first line agent for the treatment of acute dystonic reactions. See how to administer and dose this drug.
Heinrich von Bamberger
Heinrich von Bamberger (1822 - 1888) was an Austrian physician. Bamberger sign in pericardial effusion (1856); Bamberger-Concato disease
William West
William James West (1794-1848) described West Syndrome (Infantile Spasms) - Triad of infantile spasms, developmental delay and hypsarrhythmia
Dimercaprol
This rarely used intramuscular chelator is the most toxic of all chelating agents, and is reserved for the treatment of severe poisoning from lead, inorganic arsenic and mercury, if possible EDTA or Succimer should be used instead.
Desferrioxamine
Desferrioxamine is an effective iron chelator that is used to treat systemic iron toxicity or prevent the development of systemic toxicity following acute iron overdose. It should ideally be given before iron moves intracellularly and systemic toxicity develops.
Sutton’s Law
Sutton's law: When making a diagnosis one should first consider the obvious, and conduct tests which could confirm/ rule out the most likely diagnosis.
Dicobalt edetate
Dicobalt edetate was developed as a cyanide antidote based on the known ability of cobalt to form stable complexes with cyanide.
CICM SAQ 2013.2 Q13
Questions 13.1 A 52-year-old female was admitted the previous night with an altered level of consciousness that improved rapidly with administration of glucose. She is referred to ICU the next day with confusion, ataxia and a worsening level of consciousness.…