Johannes “Jan” Peutz
Johannes Laurentius Augustinus Peutz (1886 - 1957) was a Dutch physician. Peutz-Jeghers syndrome (1921)
Category Gastroenterology
Einar Meulengracht
Jens Einar Meulengracht (1887 - 1976) was a Danish physician. Meulengracht ikterus index; Meulengracht diet; Gilbert syndrome
Portal vein thrombosis
Portal vein thrombosis: thrombus formation in the portal vein +/- tributaries (superior mesenteric vein, IMV and splenic vein)
Spontaneous Bacterial Peritonitis
Spontaneous Bacterial Peritonitis: often occurs in patients with severe hepatic dysfunction -> should lead to transplantation consideration if appropriate
Portal Hypertension
Portal Hypertension = increased resistance to flow through liver -> shunted around the other collateral vascular beds; the most common complication of cirrhotic liver disease
Hepatic veno-occlusive disease
Hepatic veno-occlusive disease aka sinusoidal obstruction syndrome (SOS) important complication of stem cell transplantation (SCT) mortality >30%
Acute Cholangitis
Acute or ascending cholangitis is a potentially life-threatening systemic infection resulting from inflammation and infection of the biliary tree due to bacterial growth in the bile, usually in the context of biliary obstruction
Gastrointestinal Literature Summaries
Gastrointestinal Literature Summaries
Coagulopathy in Liver Dysfunction
Coagulopathy in Liver Dysfunction; defined as INR >1.5 due to liver dysfunction; patients are not 'auto-anticoagulated' - they are often in a procoagulant state!
Clostridium difficile and PMC
Pseudomembranous colitis (PMC); acute inflammatory disease of colon commonly associated with antibiotic use; C. difficile implicated as a causative organism in 1970’s
Portopulmonary syndrome
Portopulmonary Syndrome is NOT considered contraindication to liver transplantation; affects ~20% of pre-transplant patients; usually due to increased blood flow through the lungs without increased resistance
Hepatopulmonary Syndrome
Hepatopulmonary Syndrome = hepatic dysfunction + intrapulmonary vasodilation -> gas exchange abnormalities; imbalance between intrapulmonary vasoconstriction and vasodilation at the pre- and post-capillary level