Antimicrobial Dosing and Kill Characteristics
Dosing is different to non-critically ill patients
Different antimicrobials have different kill characteristics, which can be demonstrated on a concentration vs time graph for antibiotic activity
Category Medical Specialty
Paediatric Asthma
See RCH Melbourne Guidelines:
ILCOR Guideline Changes 2010
ILCOR = International Liaison committee on Resuscitation = conglomerate of resuscitation councils worldwide. Changes in 2010
Clenbuterol toxicity
Reviewed and revised 24 May 2014 OVERVIEW MECHANISM OF ACTION TOXICOKINETICS RISK ASSESSMENT CLINICAL FEATURES Effects include: Complications INVESTIGATIONS (Guided by clinical assessment) Laboratory tests MANAGEMENT Resuscitation Supportive care and monitoring Decontamination Disposition References and Links Journal articles
Renal replacement therapy: Fluid Management
Renal replacement therapy: Fluid Management
Ethanol Intoxication, Abuse and Dependence
Ethanol (ethyl alcohol) is an aliphatic alcohol, C2H5OH. The primary effect of ethanol is CNS depression, which is additive with other CNS depressants
High-dose Insulin Euglycaemic Therapy
High-dose Insulin Euglycaemic Therapy (HIET) is primarily used in the therapy of severe calcium channel blocker toxicity. HIET can also be used for severe beta blocker toxicity and potentially other toxicities/ presentations requiring inotropic support
Amphetamine Toxicity
Sympathomimetic syndrome with potential for life-threatening vascular complications (ischemia, dissection and haemorrhage). Note: ecstasy is also associated with hyponatraemia
End-Stage Renal Failure
End-stage renal failure has multiple implications for ICU management
Fluid Responsiveness
Fluid responsiveness is an increase of stroke volume of 10-15% after the patient receives 500 ml of crystalloid over 10-15 minutes (as defined by Paul Marik). The definitive test for fluid responsiveness is a Fluid challenge
Drug Withdrawal States in ICU
Drug withdrawal in ICU is more common than generally appreciated.
Haemoperfusion
Haemoperfusion: Renal replacement therapy (RRT) using an adsorbent cartridge to remove circulating toxins