Lenègre-Lev disease


Lenègre-Lev disease: Acquired complete heart block. Fibrous transformation progressive and slow, of degenerative origin, of the two branches of the bundle of His, resulting in progressive conductional disorders:

  • block of branch with or without hemibloc of the opposite side
  • then complete, paroxysmal then permanent block of auriculoventricular (disease of Adams-Stokes).

The prognosis of Lenègre’s disease has been transformed by the development of electrical pacing.


1964Jean Lenègre, of the Hopital Boucicaut in Paris, described progressive fibrosis of the ventricular conduction system in a series of articles published in French in the 1950s; his first and major reference in English appeared in 1964 [PMID 14153648]

1964Maurice Lev, of the University of Miami, saw a similar sclerodegenerative process, often with calcification, in an older age group [PMID 14237429]

Both processes are manifested as fascicular conduction defects shown in the electrocardiogram, somewhat more rapidly progressing toward complete atrioventricular block in Lenegre’s disease than in Lev’s

Semantically, both are diseases – as originally proposed by Rosenbaum (1970) – rather than syndromes: Each consists of an essentially monocomponent pathology.

Associated Persons

Alternate names

  • Lev’s disease
  • Lenègre’s disease
  • Maladie de Lenègre (fibrose des deux branches du faisceau de His à l’origine de troubles progressifs de la conduction)


Described independently by Jean Lenègre and Maurice Lev in 1964. Generally referred to as Lev’s disease. However, Lenègre published (in French) the condition 10 years earlier.

Nikolic G 1983 Lenegre-lev disease
Nikolic G 1983 Lenegre-lev disease


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the names behind the name

Emergency physician MA (Oxon) MBChB (Edin) FACEM FFSEM with a passion for rugby; medical history; medical education; and informatics. Asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | vocortex |

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