Pulmonary Toxicity of Chemotherapy
Pulmonary Toxicity of Chemotherapy
Neurological Toxicity of Chemotherapy
Neurological Toxicity of Chemotherapy: Encephalopathy; Cerebellar Syndrome; Myelopathy; Peripheral Neuropathy; Stroke and Venous Thrombosis; SIADH
Metabolic Toxicity of Chemotherapy
Metabolic Toxicity of Chemotherapy: Disorders related to the Tumour; disorders related to Anticancer Agents
Coagulation Profile
OVERVIEW PROTHROMBIN TIME -> warfarin-> vitamin K deficiency-> liver disease-> DIC-> artefact: incorrect sampling or increased haematocrit (> 55%) ACTIVATED PARTIAL THROMBOPLASTIN TIME -> heparin-> DIC-> haemophilia-> liver disease THROMBIN TIME -> heparin-> DIC-> hypofibrinogenaemia-> fibrin degradation products FIBRINOGEN ->…
D-dimer
D-dimer specific for fibrin breakdownsensitivity = 95%specificity = 50%
Full Blood Count
FBC - full blood count; FBE - full blood examination; FBP - full blood picture
Platelet Function Assays
PFA-100 = citrated whole blood placed in a disposable cartridge containing a membrane coated with collagen/adrenaline or collagen/ADP into which a microscopic aperture has been cut -> with high shear rates contact of blood with the membrane causes platelets to aggregate and occlude the aperture.
Thromboelastogram (TEG)
Thromboelastography (TEG) is a viscoelastic hemostatic assay that measures the global viscoelastic properties of whole blood clot formation under low shear stress
Thrombophilia Screen
Thrombophilia is a predisposition to increased risk of venous and arterial thromboembolism due to haemostatic abnormalities
VBG versus ABG
Reviewed and revised 7 January 2016 OVERVIEW Venous blood gases (VBG) are widely used in the emergency setting in preference to arterial blood gases (ABG) as a result of research published since 2001 The weight of data suggests that venous pH…
Abdominal Ultrasound
abdominal ultrasound findings for important critical care diagnoses