FFS: Lateral medullary syndrome

Lateral medullary syndrome (also known as Wallenberg syndrome) is is a stroke syndrome, which develops as a result of infarction in the region of the brainstem supplied by the posterior inferior cerebellar artery (PICA), which is a branch of the vertebral artery.

Affected structures include:

  • Lateral aspect of the medulla oblongata
  • Inferior cerebellar peduncle
  • Infero-lateral cerebellum.

It is an uncommon syndrome.

The diagnosis is often missed, (even by experienced neurologists), but it is important to understand the syndrome in order to fully appreciate the potential extent of disability that can be suffered by the patient, (over and above the most obvious feature of ataxia

Thrombolysis is an option in the astute setting, however, it  has a high degree of risk within this region. Hemorrhagic complications within the brainstem will carry a significant risk of death.

The risk -versus benefit of this intervention must be carefully assessed by expert neurologist experienced in stroke neurointervention


History

Adolf Wallenberg (1862-1949), a German neurologist, described the syndrome in 1895 and published a precise anatomical description in 1901. However, the first recorded case was by Gaspard Vieusseux (1746-1814), who described his own symptoms at a medical meeting in Geneva in 1808.


Epidemiology

Lateral medullary syndrome is the most common and important syndrome related to intracranial vertebral artery occlusion.

Anatomy

The lateral medulla contains:

  1. Motor nuclei for cranial nerves IX, X, and XI.
  2. Sensory nucleus (nucleus solitarius) for cranial nerves VII, IX, and X.
  3. Trigeminal sensory nucleus, mainly in the pons but extending through the brainstem.

Note: The hypoglossal and dorsal vagal nuclei are in the medial medulla.


Pathophysiology

The syndrome results from occlusion—commonly thrombosis or embolism, rarely dissection—of vessels supplying the lateral medulla and infero-lateral cerebellum.

Arterial supply includes:

  • Vertebral artery branches
  • Posterior inferior cerebellar artery (PICA) — supplies the dorsal lateral medulla and posterior medial cerebellum

Most cases are due to vertebral artery occlusion; less often due to PICA occlusion.


Clinical features
Symptoms

Typically acute onset of:

  • Vertigo
  • Vomiting
  • Dysphagia
  • Dysarthria
  • Ataxia
Signs
Ipsilateral findingsContralateral findings
Horner syndrome (ptosis, miosis, hypohidrosis or anhidrosis, enophthalmos, due to damage to descending sympathetic fibers)Spinothalamic loss (pain/temp) in limbs
Cerebellar signs, nystagmus
Cranial nerves IX, X palsy (palatal paralysis, loss of taste posterior 1/3 tongue)
Trigeminal spinothalamic loss in the face

Investigations

Blood tests:

  1. FBC
  2. CRP (potential arteritis)
  3. U&Es / glucose
  4. Coagulation profile
  5. Others as clinically indicated

ECG — assess for atrial fibrillation

CT scan / CT angiogram / CT perfusion scan — per stroke protocols

MRI — best imaging for infarct definition. MRI with diffusion‐weighted imaging (DWI) is the best diagnostic test to confirm the infarct in the lateral medulla. The infarcted area has a high DWI signal and a low signal on apparent diffusion coefficient (ADC) mapping images.

Echocardiography and carotid Doppler — if embolic source suspected


Management
  1. ABC support
  2. Initiate local CODE STROKE protocols as for any suspected stroke syndrome
  3. Standard ischaemic stroke protocols should be initiated
    • Neurointervention with thrombolysis and/ or endovascular clot retrieval may be appropriate in selected cases for patients who present <24 hours.
    • Neurointervention has a high degree of risk within this region. Haemorrhagic complications within the brainstem will carry a significant risk of death
    • The risk -versus benefit of this intervention must be carefully assessed by expert neurologist experienced in stroke neurointervention
  4. Nil orally (in the first instance).
  5. IV fluids
  6. Speech therapy referral
  7. Antiplatelet therapy in those not suitable for neurointervention therapies (e.g., aspirin via NGT if swallowing impaired)
  8. Speech therapy referral once stable

Prognosis

Prognosis varies based on infarct size and location and timing of intervention.

  • Early deaths can result from aspiration or sleep apnoea.
  • Many recover significantly over weeks to months.
  • Some may have lasting neurological deficits.

Appendix 1

The Cerebral Circulation
The Cerebral Circulation; N Engl J Med 2005;352:2618-26

Appendix 1

Arterial vasculature of the brainstem
Arterial vasculature of the brainstem – Circle Of Willis, (Wikipedia).

Appendix 2

Transverse section through the medulla oblongata at the level of the olives
Transverse section through the medulla oblongata at the level of the olives. The region supplied by the posterior inferior cerebellar artery is circled in red

Appendix 3

lateral medullary infarct
Magnetic resonance imaging scan showing a small infarct in lateral medulla of the right side (Kim, 1994)

References

Publications

FOAMed

Fellowship Notes

MBBS DDU (Emergency) CCPU. Adult/Paediatric Emergency Medicine Advanced Trainee in Melbourne, Australia. Special interests in diagnostic and procedural ultrasound, medical education, and ECG interpretation. Co-creator of the LITFL ECG Library. Twitter: @rob_buttner

Dr James Hayes LITFL Author Medical Educator

Educator, magister, munus exemplar, dicata in agro subitis medicina et discrimine cura | FFS |

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