Toxicology-Library-Toxicant-Drug-340-256
Organochlorines

Chlorinated pesticides are widely used in agriculture but the most common source or organochlorines is Lindane, used for the treatment of head lice. Acute ingestion or repeated large dermal expose causes neurological toxicity which can lead to seizures and a coma.

Toxicology-Library-Toxicant-Drug-340-256
Hydrogen peroxide

Hydrogen Peroxide is an oxidising agent used widely in domestic and industrial products. It causes damage by three main mechanisms: direct corrosive injury, oxygen gas formation and lipid peroxidation.

Toxicology-Library-Toxicant-Drug-340-256
Hydrofluric acid

Hydrofluoric acid is found in car wheel cleaners, rust removal and glass etching solutions. Classically the person will present with pain out of proportion hours after dermal exposure.

Toxicology-Library-Toxicant-Drug-340-256
Glyphosate toxicity

Glyphosate is a widely used herbicide. It can cause gastrointestinal corrosive symptoms and due to the surfactant that is present a severe metabolic acidosis, hyperkalaemia and cardiovascular collapse can occur.

Toxicology-Library-Toxicant-Drug-340-256
Corrosive ingestions

Corrosive ingestion: Patients who are asymptomatic at 4 hours and tolerating oral fluids can be medically cleared. Symptomatic patients need to remain nil by mouth and are admitted for observation and further investigation within 24 hours. Management is then directed dependent on these findings.