CCC Critical Care compendium 340
Global Increased Permeability Syndrome

Global Increased Permeability Syndrome (GIPS) "is characterised by high capillary leak index (CLI, expressed as the ratio of CRP over albumin x 100), excess interstitial fluid and persistent high extravascular lung water index (EVLWI), no late conservative fluid management (LCFM) achievement, and progression to organ failure"

CCC Critical Care compendium 340
Medical futility

"Futility" means the absence of benefit; a consensus definition of medical futility does not exist; ~80% of ICU patients who die do so as a consequence of a decision to withhold or withdraw life support

CCC Critical Care compendium 340
Heliox

Heliox is a mixture of helium and oxygen, by substituting helium for nitrogen -> reduction in density of the gas -> reduction in Reynolds number -> more laminar flow -> reduces airflow resistance, work of breathing and dynamic hyperinflation