CCC Critical Care compendium 340
Randomisation

Randomisation is the process of assigning clinical trial participants to treatment groups such that each participation has a known (usually equal) chance of being assigned to any of the groups

CCC Critical Care compendium 340
Early Stopping of Trials

Reviewed and revised 26 August 2015 OVERVIEW Clinical trials are planned to stop when one of the following is reached sample size  event count length of follow up goal scheduled date of closure Unplanned early stopping of trials may occur…

CCC Critical Care compendium 340
Risk and Numbers Needed to Treat

Risk is a nebulous term in evidence-based medicine, as it may refer to either relative or absolute risks. Overall, absolute risks are more meaningful and can be converted in 'numbers need to treat' (NNT), which are useful in the clinical setting

CCC Critical Care compendium 340
Case-Control Studies

Case-Control Studies: a type of retrospective observational study; control patients are ‘matched’ using some criteria (age, gender), typically should have no history of the disease of interest and should be representative of the general population

CCC Critical Care Compendium 680
Urate (Uric Acid)

Uric acid is the major end metabolite of purine. Purine found in nucleic acid and exogenous sources; Commonly used as marker for gout and pre-eclampsia; Levels do not usually indicate severity of disease