Portopulmonary syndrome
Portopulmonary Syndrome is NOT considered contraindication to liver transplantation; affects ~20% of pre-transplant patients; usually due to increased blood flow through the lungs without increased resistance
Category Medical Specialty
Storage Lesions
Storage lesions are the adverse effects associated with the storage of blood; begins after about 2 weeks of storage and progresses with duration of storage ('RBC age')
Aerobic Gram Positive Bacteria
Aerobic gram positive bacteria
Infective Endocarditis
infective endocarditis is a disease characterised by inflammation of the endocardium, typically affecting the heart valves and usually caused by infection and can be acute, subacute or chronic
Hepatopulmonary Syndrome
Hepatopulmonary Syndrome = hepatic dysfunction + intrapulmonary vasodilation -> gas exchange abnormalities; imbalance between intrapulmonary vasoconstriction and vasodilation at the pre- and post-capillary level
Chronic Liver Disease
Chronic Liver Disease
Blood Transfusion Risks
Blood transfusion complications may be early or late
Blood Conservation Strategies
Anemia and blood transfusion is common in the critically ill, and are associated with costs and morbidity/ mortality
Tumour Lysis Syndrome
Tumour Lysis Syndrome: oncological emergency due to turnover of high cell mass malignancies resulting in severe metabolic derangement
von Willebrand Disease
von Willebrand Disease: commonest inherited coagulation disorder (autosomal dominant); protein involved in (1) platelet adhesion and (2) carriage of factor VIII; leads to: factor VIII deficiency, abnormal platelet adhesiveness and abnormal vascular endothelium
VTE Prophylaxis
Venous thromboembolism (VTE) may contribute to up to 12% of deaths in ICU and is the No.1 preventable cause of hospital death; asymptomatic events range from 10-80% in various medical and surgical groups
Porphyria
OVERVIEW Porphyria = group of disorders where patients have a inability to synthesis Hb resulting in an accumulation of precursors oxidised to porphyrins hepatic and erythropoietic varieties 3 hepatic forms that effect are affected by anaesthesia (1) AIP – acute…