Phenothiazines and butyrophenones are the antipsychotic (neuroleptic) agents. Commonly used agents are chlorpromazine, prochlorperazine, droperidol and haloperidol. Other unfamiliar agents include fluphenazine, Pericyazine, Pipothiazine and Trifluoperazine
Risperidone is an atypical antipsychotic agent associated with tachycardia and acute dystonic reactions.
Have a listen to some of the eclectic toxicology lectures from around the world as we manage to catch these speakers in action.
Calcium channel blockers are not all born the same. Some produce severe cardiotoxic effects which in the past has caused significant mortality and others cause severe peripheral vasodilatation
Beta blocker overdoses can be relatively benign but a couple can causes serious cardiotoxicity and even death if not managed aggressively.
Clonidine has a vast array of uses including anxiety, ADHD, hypertension, withdrawal (opitates, alcohol and smoking), migraines, menopausal flushing, diarrhoea and finally pain. It causes the classic triad of drowsiness, miosis and bradycardia in overdose.
Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences.
OSCE 10: Paediatric Iron Overdose. OSCEs done by recent fellows at a high level to provide an example of a good pass and additional advice on providing a framework to answer the scenarios.
OSCE 9: Overdose Advice. OSCEs done by recent fellows at a high level to provide an example of a good pass and additional advice on providing a framework to answer the scenarios.
A young male is unconscious and on his way to your hospital. Bystanders confirm he has been depressed and taken an overdose. The paramedics are worried about his ECG..."it looks weird and his QRS is very wide". The following tox tute will guide you through managing this patient.
Mirtazapine is a novel tetracyclic antidepressant, in overdose it frequently has a benign course with mild CNS depression and tachycardia.
SNRIs or Selective serotonin and noradrenaline reuptake inhibitors are mainly in the form of venlafaxine and desvenlafaxine. Venlafaxine in overdose can be potentially life threatening, causing seizures and cardiotoxicity.