That’s right, SMACC SimWars is turning into a global conflict. Hot on the heels of EMCrit’s Scott Weingart announcing himself to be one of SMACC’s elite SimWars judges (and confessing his delight in the sadistic elements of his co-creation), the…
The newly formed Southern Hemisphere Information Technology '4 brains' group have covertly implemented a series of strategies within Australian hospitals which they are confident will coagulate productivity to a state of suppuration.
An essential co-factor in the synthesis of clotting factors II, VII, IX and X. It is used for the reversal of coumadin-induced coagulopathy.
Sugammadex is used for reversal of the amino steroid neuromuscular blocking drugs rocuronium, vecuronium and pancuronium. It does not work on non-amino steroid neuromuscular blocking drugs (atracurium, cisatracurium and suxamethonium).
Succimer (DMSA) is an orally active metal chelator is used to treat heavy metal poisoning. In adults Succimer is used for symptomatic lead poisoning or in patients who are asymptomatic with levels >60 micrograms/dL (>2.9 micro mol/L). In paediatrics it is used for symptomatic lead poisoning or in patients who are asymptomatic with levels >45 micrograms/dL (>2.17 micro mol/L).
Sodium Thiosulfate enhances the endogenous cyanide detoxification capacity of the body. It is suitable to use alone in the treatment of mild to moderately severe cases of cyanide poisoning but should be used in conjunction with other antidotes such as hydroxocobalamin in severe cyanide toxicity.
Sodium Calcium Edetate (EDTA) is an intravenous heavy metal chelating agent. EDTA is primarily used in the treatment of severe lead poisoning with or without lead encephalopathy or an asymptomatic/mildly symptomatic patient with a serum lead level >70 microgram/dL (3.38 micro mol/L).
Hyperosmolar sodium bicarbonate solutions are widely used in clinical toxicology both as an antidote to drugs that impair fast sodium channel function and as an alkalinising agent to manipulate drug distribution and excretion (salicylate and phenobarbitone). It is also used in profound metabolic acidosis with cyanide, isoniazid and toxic alcohol toxicity.
Intravenous pyridoxine is used in high doses to control the metabolic acidosis and seizures associated with isoniazid overdose and poisoning from other hydrazine compounds (Gyromitra mushrooms and jet/rocket fuel). It is also used as a adjunct to ethylene glycol toxicity
Pralidoxime reactivates acetylcholinesterase only if irreversible binding to the OP has not already occurred ("ageing"). The acetylcholinesterase enzyme has two parts to it. In organophosphate poisoning, an organophosphate binds to just one end of the acetylcholinesterase enzyme (the esteric site), blocking its activity.
A reversible acetylcholinesterase inhibitor useful in the treatment of central anticholinergic delirium that is not easily controlled by benzodiazepine sedation and there is high risk for aspiration and excessive sedation. Only for those patients who have an isolated anticholinergic agent toxicity (not the polypharmacy overdose).
Potent oral chelating agent for a broad range of heavy metals. Agent of choice in very few scenarios due to poor side-effect profile and the existence of better tolerated and more efficacious agents. If possible EDTA or Succimer should be used instead.