Activated Charcoal
Activated Charcoal: decontamination agent; absorbing molecules of drug on its surface -> inhibiting their absorption by as much as 50% -> excretion in faeces
Renal replacement therapy: Dose
Optimal dose of renal replacement therapy (RRT) is controversial... the definition of dose in clinical practice is also a little controversial!
Renal Literature Summaries
Renal Literature Summaries
Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) Circuits: used in renal replacement therapy; therapeutic plasma exchange; and haemoperfusion
Sepsis Literature Summaries
Sepsis Literature Summaries
Opioid Withdrawal
Opioid Withdrawal
Opioid Overdose
Opioid Overdose: miosis; CNS depression; respiratory depression; complications of hypoxia: seizures, dysrrhythmia, brain injury
Paraquat Poisoning
Paraquat Poisoning; highly toxic herbicide; common agent in suicide in 3rd world; leading single agent causing death from pesticide poisoning in many countries including Sri Lanka
Sedative Toxidrome
Sedative toxidrome: agents - opioids; benzodiazepines; barbiturates; baclofen (may mimic brain death, suspect in MS patients); clonidine (mimics opioid toxidrome with marked bradycardia and hypotension)
GHB
SIADH DDx
SIADH = Syndrome of inappropriate antidiuretic hormone secretion. Important cause of HYPOnatraemia
Hyperkalaemia DDx
Overview Causes Increased potassium intake (rare) Increased release from tissues Decreased renal excretion Transcellular shift Factitious (Pseudo-hyperkalaemia) Drugs causing hyperkalaemia References and Links LITFL
Randomisation
Randomisation is the process of assigning clinical trial participants to treatment groups such that each participation has a known (usually equal) chance of being assigned to any of the groups