CCC Critical Care compendium 340
Neutropaenic Sepsis

Febrile neutropaenia (or neutropaenic fever) is defined as: a single temperature measurement >=38.5C, or a sustained temperature >=38C for more than 1 hour; in a patient with a decreased absolute neutrophil count (ANC) of either <0.5 x 109/L, or <1 x 109/L with a predicted nadir of <0.5 x 109/L over the subsequent 48h

CCC Critical Care compendium 340
Hepatorenal Syndrome

Hepatorenal Syndrome = profound oliguria and Na+ retention in the setting of severe liver dysfunction (cirrhosis or fulminant liver failure); usually fatal unless liver transplant performed. RRT can prevent advancement of condition

CCC Critical Care compendium 340
Sepsis Pathophysiology

OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK =…

CCC Critical Care compendium 340
Corticosteroid Therapy for Shock

Corticosteroids are widely used in patients with refractory septic shock, as well as other selected causes of shock. Despite numerous trials, the role of corticosteroids in septic shock remains a controversial issue... still!