CCC Critical Care compendium 340
Hyperbaric oxygen for carbon monoxide poisoning

Reviewed and revised 27 December 2013 OVERVIEW MECHANISM OF CARBON MONOXIDE TOXICITY Effects of CO toxicity include those of acute hypoxia as well as delayed neurological sequelae, that are more prominent with chronic exposure RATIONALE FOR HYPERBARIC OXYGEN THERAPY CO…

CCC Critical Care compendium 1200
Isoniazid toxicity

Isoniazid toxicity, like other hydrazines, primarily cause life-threatening seizures and lactic acidosis through depletion of vitamin B6. The antidote is pyridoxine

CCC Critical Care Compendium 680
Acute Paracetamol Toxicity

Acute Paracetamol Toxicity: following overdose glucuronidation and sulphation pathways are rapidly saturated -> increased metabolism to NAPQI (N-acetyl-P-benzoquineimine); glutathione is required to inactivate NAPQI and when levels depleted -> hepatocellular death takes place

CCC Critical Care compendium 340
CK-MB

CK-MB: creatine kinase dimer of M and B chains; found mainly in myocardial cytosol (also in skeletal muscle); one of three isoenzymes of creatine kinase (CK)

  • creatine kinase dimer of M and B chains
  • found mainly in myocardial cytosol (also in skeletal muscle)
  • one of three isoenzymes of creatine kinase (CK)

CCC Critical Care compendium 340
CRP

CRP = C-reactive protein OVERVIEW discovered in 1930 by studying Streptococcus pneumoniae infection -> named for its ability to bind to the somatic C-polysaccharide of such bacterial belongs to the family of pentraxins (calcium dependent ligand-binding plasma proteins) Normal range…