Bartter Syndrome

Bartter syndrome refers to a group of renal tubulopathies characterised by hypokalaemic metabolic alkalosis, elevated renin and aldosterone levels, normal or low blood pressure and polyuria. Classically, a defect in the NKCC2 co-transporter of the thick ascending limb causes renal salt wasting, leading to chronic volume depletion. This activates the renin–angiotensin–aldosterone…