Leukodepleted Blood
OVERVIEW
- RBCs used for transfusion in Australia and New Zealand are now universally leukodepleted
- leukodepletion filters were previously used at the bedside
THEORETICAL BENEFITS
- decreases risk of TRALI
- reduction in non-haemolytic transfusion reactions
- reduction in CMV transmission
- improved chance of finding an organ transplant match if required
- reduction in storage lesion effect
- reduction in graft vs host disease
EVIDENCE
- reduction in mortality after universal leukodepletion in cardiac surgical, orthopedic and trauma populations (Hebert, JAMA, 2003)
- no RCTs
References and links
CCC
Blood products:
– Blood Product Compatibilities
– Cryoprecipitate
– Leukodepleted Blood
– Fibrinogen Concentrate
– Prothrombinex-VF
Reversal:
– Dabigatran and Bleeding
– Procedures and Coagulopathy
– Rivaroxaban and Bleeding
General:
– Acute Coagulopathy of Trauma
– Blood Bank
– Blood Conservation Strategies
– Blood Transfusion in ICU
– Blood Transfusion Risks
– Disseminated Intravascular Coagulation
– Massive Blood Loss
– Massive Transfusion Protocol
– Storage Lesions
– Transfusion literature summaries
– TRALI
Coagulation studies:
– Coagulation Profile
– Platelet function assays
– Thrombolelastography
[cite]
Critical Care
Compendium
Chris is an Intensivist and ECMO specialist at The Alfred ICU, where he is Deputy Director (Education). He is a Clinical Adjunct Associate Professor at Monash University, the Lead for the Clinician Educator Incubator programme, and a CICM First Part Examiner.
He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives. He was one of the founders of the FOAM movement (Free Open-Access Medical education) has been recognised for his contributions to education with awards from ANZICS, ANZAHPE, and ACEM.
His one great achievement is being the father of three amazing children.
On Bluesky, he is @precordialthump.bsky.social and on the site that Elon has screwed up, he is @precordialthump.
| INTENSIVE | RAGE | Resuscitology | SMACC
