Leukodepleted Blood
OVERVIEW
- RBCs used for transfusion in Australia and New Zealand are now universally leukodepleted
- leukodepletion filters were previously used at the bedside
THEORETICAL BENEFITS
- decreases risk of TRALI
- reduction in non-haemolytic transfusion reactions
- reduction in CMV transmission
- improved chance of finding an organ transplant match if required
- reduction in storage lesion effect
- reduction in graft vs host disease
EVIDENCE
- reduction in mortality after universal leukodepletion in cardiac surgical, orthopedic and trauma populations (Hebert, JAMA, 2003)
- no RCTs
References and links
CCC
Blood products:
– Blood Product Compatibilities
– Cryoprecipitate
– Leukodepleted Blood
– Fibrinogen Concentrate
– Prothrombinex-VF
Reversal:
– Dabigatran and Bleeding
– Procedures and Coagulopathy
– Rivaroxaban and Bleeding
General:
– Acute Coagulopathy of Trauma
– Blood Bank
– Blood Conservation Strategies
– Blood Transfusion in ICU
– Blood Transfusion Risks
– Disseminated Intravascular Coagulation
– Massive Blood Loss
– Massive Transfusion Protocol
– Storage Lesions
– Transfusion literature summaries
– TRALI
Coagulation studies:
– Coagulation Profile
– Platelet function assays
– Thrombolelastography
Cite this article as: Chris Nickson, "Leukodepleted Blood," In: LITFL - Life in the FastLane, Accessed on March 26, 2023, https://litfl.com/leukodepleted-blood/.
Critical Care
Compendium
Chris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. He is also a Clinical Adjunct Associate Professor at Monash University. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. He is on the Board of Directors for the Intensive Care Foundation and is a First Part Examiner for the College of Intensive Care Medicine. He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives.
After finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. He has completed fellowship training in both intensive care medicine and emergency medicine, as well as post-graduate training in biochemistry, clinical toxicology, clinical epidemiology, and health professional education.
He is actively involved in in using translational simulation to improve patient care and the design of processes and systems at Alfred Health. He coordinates the Alfred ICU’s education and simulation programmes and runs the unit’s education website, INTENSIVE. He created the ‘Critically Ill Airway’ course and teaches on numerous courses around the world. He is one of the founders of the FOAM movement (Free Open-Access Medical education) and is co-creator of litfl.com, the RAGE podcast, the Resuscitology course, and the SMACC conference.
His one great achievement is being the father of three amazing children.
On Twitter, he is @precordialthump.
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