Tranexamic Acid
Tranexamic Acid (TXA): anti-fibrinolytic agent with many uses in preventing haemorrhage that rose to prominence following the CRASH-2 study showing a mortality benefit in trauma patients
Post-intubation hypoxia
Post-intubation hypoxia can be rapidly fatal without early intervention, which requires a structured approach to concurrently identifying and treating the underlying cause
Dabigatran and Bleeding
Dabigatran is a direct thrombin inhibitor; It is viewed as a warfarin replacement; It's use is controversial because the management of bleeding complications is difficult and there is no definitive antidote
Respiratory Alkalosis DDx
Respiratory Alkalosis DDx
Respiratory Acidosis DDx
Respiratory Acidosis DDx
Metabolic acidosis DDx
Metabolic acidosis DDx
Urea
Urea (Blood Urea Nitrogen – BUN) is the chief end product of protein metabolism. it is formed in the liver from ammonia and excreted by the kidneys. Urea accounts for 50% of serum non-protein nitrogen Causes of Increased serum urea…
Hypomagnesaemia
Hypomagnesaemia: Defined as serum magnesium < 0.75 mmol/L; associated with increased ICU mortality common — affects 10-65% of ICU patients
Arterial Blood Gas Sample
Indications: Evaluate the adequacy of ventilation, acid–base status, and oxygenation. Evaluate the patient’s response to therapy and/or diagnostic evaluation (e.g. oxygen delivery). Monitor severity and progression of a known disease process. Contraindications: Modified Allen test gives a negative result, indicating…
Methanol Toxicity
Methanol Toxicity
Regional citrate anticoagulation
Regional Citrate Anticoagulation is the infusion of citrate into the blood circuit during renal replacement therapy (RRT) to chelate ionized Ca2+ forming calcium-citrate complexes, thus preventing coagulation of blood; calcium is required for the generation of thrombin (involved in the activation of factors II, IX and X)
Malignant Hyperthermia
Malignant Hyperthermia = pharmacogenetic disease of skeletal muscle induced by exposure to certain anaesthetic agents; incidence 1:5,000 -> 1:65,000 anaesthetics (suspected); mutation in the gene coding for the ryanodine receptor