CCC Critical Care Compendium 680
Ataxia DDx

Ataxia is impaired coordination in the absence of weakness. Acute ataxia is a neurological emergency, and vascular lesions of the cerebellum (infarction, hemorrhage) must be considered/ excluded.

CCC Critical Care compendium 340
Unresolved sepsis

When a 'septic' patient fails to improve despite initial therapy, it is important to 'stop and think' and systematically consider the multiple possible reasons why 'the antibiotic is not working'

CCC Critical Care compendium 340
Mitochondrial dysfunction

Mitochondria are the intracellular organelles that produce the bulk of the body’s energy currency (ATP). they are derived from endosymbiotic prokaryotes around the time of the origin of eukaryotic cells

CCC Critical Care compendium 340
Oxygen-Haemoglobin Dissociation Curve

sigmoid shape of the oxy-Hb dissociation curve results from the allosteric interactions of the globin monomers that make up the haemoglobin tetramer as each one binds O2. Multiple factors can affect the affinity of Hb for oxygen, thus causing the curve to shift to the left (increased oxygen affinity) or to the right (decreased O2 affinity)