Left Ventricular Hypertrophy Overview
- The left ventricle hypertrophies in response to pressure overload secondary to conditions such as aortic stenosis and hypertension.
- This results in increased R wave amplitude in the left-sided ECG leads (I, aVL and V4-6) and increased S wave depth in the right-sided leads (III, aVR, V1-3).
- The thickened LV wall leads to prolonged depolarisation (increased R wave peak time) and delayed repolarisation (ST and T-wave abnormalities) in the lateral leads.
Criteria for Diagnosing LVH
- There are numerous criteria for diagnosing LVH, some of which are summarised below.
- The most commonly used are the Sokolov-Lyon criteria (S wave depth in V1 + tallest R wave height in V5-V6 > 35 mm).
- Voltage criteria must be accompanied by non-voltage criteria to be considered diagnostic of LVH.
- R wave in lead I + S wave in lead III > 25 mm
- R wave in aVL > 11 mm
- R wave in aVF > 20 mm
- S wave in aVR > 14 mm
- R wave in V4, V5 or V6 > 26 mm
- R wave in V5 or V6 plus S wave in V1 > 35 mm
- Largest R wave plus largest S wave in precordial leads > 45 mm
Non Voltage Criteria
- Increased R wave peak time > 50 ms in leads V5 or V6
- ST segment depression and T wave inversion in the left-sided leads: AKA the left ventricular ‘strain’ pattern
Additional ECG changes seen in LVH
LVH by voltage criteria: S wave in V2 + R wave in V5 > 35 mm
LV strain pattern: ST depression and T wave inversion in the lateral leads
Causes of LVH
- Hypertension (most common cause)
- Aortic stenosis
- Aortic regurgitation
- Mitral regurgitation
- Coarctation of the aorta
- Hypertrophic cardiomyopathy
- Voltage criteria alone are not diagnostic of LVH
- ECG changes are an insensitive means of detecting LVH (patients with clinically significant left ventricular hypertrophy seen on echocardiography may still have a relatively normal ECG)
Left ventricular hypertrophy (LVH):
- Markedly increased LV voltages: huge precordial R and S waves that overlap with the adjacent leads (SV2 + RV6 >> 35 mm).
- R-wave peak time > 50 ms in V5-6 with associated QRS broadening.
- LV strain pattern with ST depression and T-wave inversions in I, aVL and V5-6.
- ST elevation in V1-3.
- Prominent U waves in V1-3.
- Left axis deviation.
Severe LVH such as this appears almost identical to left bundle branch block — the main clue to the presence of LVH is the excessively high LV voltages.
- There are massively increased QRS voltages — the S waves in V3 are so deep they are literally falling off the page!
- The ST elevation in V1-3 is simply in proportion to the very deep S waves (“appropriate discordance”).
- The LV strain pattern is seen in all leads with a positive R wave (V5-6, I, II, III, aVF).
This ECG was reproduced from Dr Smith’s ECG blog
- Edhouse J, Thakur RK, Khalil JM. ABC of clinical electrocardiography. Conditions affecting the left side of the heart. BMJ. 2002 May 25;324(7348):1264-7. Review. PMID: 12028984.
LITFL Further Reading
- ECG Library Basics – Waves, Intervals, Segments and Clinical Interpretation
- ECG A to Z by diagnosis – ECG interpretation in clinical context
- ECG Exigency and Cardiovascular Curveball – ECG Clinical Cases
- 100 ECG Quiz – Self-assessment tool for examination practice
- ECG Reference SITES and BOOKS – the best of the rest
- Brady WJ, Truwit JD. Critical Decisions in Emergency and Acute Care Electrocardiography
- Surawicz B, Knilans T. Chou’s Electrocardiography in Clinical Practice: Adult and Pediatric
- Wagner GS. Marriott’s Practical Electrocardiography 12e
- Chan TC. ECG in Emergency Medicine and Acute Care
- Dubin D. Rapid Interpretation of EKG’s
- Mattu A. ECG’s for the Emergency Physician
- Hampton JR. The ECG In Practice, 6e