CICM Exam Library 340
CICM SAQ 2011.1 Q10

Compare and contrast the use of continuous veno-venous haemodialysis (CVVHD), intermittent haemodialysis (IHD) and slow continuous ultrafiltration (SCUF) in the intensive care patient.

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Potassium toxicity

Potassium clearly has its potential for risks including life-threatening hyperkalaemia and cardiac arrest. It is very concerning that the slow-release preparation is available in bottles of 100 without prescription. Aggressive decontamination and haemodialysis are indicated in large overdoses.

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Mercury toxicity

Fortunately mercury poisoning is very rare. The risk of toxicity depends on the type of mercury you have been exposed to. Elemental mercury is found in thermometers, barometers, paints, and pigments, these are benign presentations unless aerosolised

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Theophylline toxicity

Theophylline has a narrow therapeutic index, both acute and chronic overdose is potentially life-threatening requiring aggressive supportive care and dialysis to ensure a good outcome

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Isoniazid toxicity

Isoniazid overdose is rare but life threatening. Isoniazid can cause refractory seizures which require the specific antidote pyridoxine. It should be thought about in cases of status epileptics where this is a relative or a potential history of TB in the family.

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Baclofen toxicity

Baclofen in overdose produces a rapid onset of delirium, respiratory depression, coma and seizures. In large overdose the patient can appear brain dead and it has resulted in the pursuit of organ donation only for the patient to wake on the operating table. The mainstay of treatment is good supportive care.