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Opioid toxicity

Opioids are obviously our bread and butter in emergency medicine, what more is there to know? This post is designed to give you a few extra tips and some idiosyncrasies with some of the other opiates to assist you in your clinical management.

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GHB toxicity

Gamma-Hydroxybutyrate - GHB has many names including: Cherry meth, liquid Fanta, Easy Lay, Fantasy, Georgia Homeboy, Liquid Ecstasy, Liquid G and most annoyingly...water. GHB is the opposite of Amphetamine, instead of making you angry and hypervigilant it depresses your CNS. It is a precursor and metabolite of gamma-aminobutyric acid (GABA - the inhibitory neurotransmitter).

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Cocaine toxicity

Cocaine is a classic sympathomimetic, used by the Incas as an appetite suppressant and noted for its analgesic properties we now use it medically as a local anaesthetic (Sodium channel blockade of the nerves).

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Cannabinoid toxicity

Marijuana is the most widely used illicit drug in Australia, most people have a pleasant experience with the psychoactive drug. Cannabinoids can have adverse effects particularly in children if high doses are consumed which result in CNS depression and a coma lasting up to 36 hours.

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Barbiturate toxicity

An uncommon presentation but you need to know that barbiturates can cause a profound coma mimicking brain death. Without good supportive care this overdose or mis-adventure can be lethal.

Letter from America
Letter From America #5

Well that's it, just like that the conference has come to end. The last few days have been a wild ride through the essentials of emergency medicine. Mel Herbert and his team have put on one hell of a show, and San Francisco played host superbly