Metformin toxicity
Metformin rarely causes hypoglycaemia but it can cause a profound lactic acidosis in overdose and in patients with renal failure.
Insulin toxicity
While insulin overdose should be simple to manage this guide will show you some of the nuances to the management and help you prevent longterm neurological impairment.
Tramadol toxicity
Tramadol in overdose would have the opiate toxidrome expected (sedation and respiratory depression) but it also can potentially cause seizures in doses >1.5 grams. Tramadol has also been associated with serotonin toxicity, rarely as a single agent but commonly with other co-ingested serotinergically active agents.
Salicylate toxicity
Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,
CICM SAQ 2011.2 Q13
You are asked to admit a 46-year-old man who has just been intubated in the Emergency Department after collapsing from what appears clinically to be a brain stem stroke. His Glasgow Coma Score prior to intubation was 6.
A Fondness of Fruit
Most of us, at one time or another, have gazed into the stratosphere and imagined clouds as familiar objects such as an animal, a face, an activity or letter of the alphabet. Such nephelococcygial activity has never resulted in my…
NICE fever guidelines for kids
Fever is the most common presentation to Paeds ED and it can be difficult to identify a focus. This causes us (me anyway) a great deal of concern.
Local Anaesthetic
Local Anaesthetic toxicity is nearly always due to a therapeutic error. Usually an incorrect dose, route or technique.
Chloral Hydrate
Chloral hydrate is used in paediatrics undergoing procedures. It was withdrawn from the adult arena due to the narrow therapeutic index. In overdue it causes rapid CNS depression, cardiac dysrhythmias and these are lethal without prompt intervention.Chloral hydrate comes in 200ml bottles, 1g/10ml
Approach to Snakebite
Potential or definite snakebite is a common presentation to Australian emergency departments.
12-lead ECG in Toxicology
The 12-lead ECG provides valuable real-time prognostic information that is based on toxic effects at the target organ; often not available from clinical evaluation or serum drug assays.
Acid base disorders and Osmolar Gaps
This is quick reference page to acid base disorders in toxicology and osmolar gaps. Zeff a toxicologist from Melbourne talks through his approach and the errors that can occur with osmolar and anion gaps.