CCC Critical Care compendium 340
Massive Transfusion Protocol

Reviewed and revised 10 March 2014 OVERVIEW Massive transfusion is defined as A Massive Transfusion Protocol should be used in critically bleeding patients anticipated to require massive transfusion GOALS IN MANAGEMENT OF MASSIVE TRANSFUSION THERAPY INDICATIONS IN MASSIVE TRANSFUSION MASSIVE TRANSFUSION…

CCC Critical Care compendium 340
Aerobic Gram Negative Bacteria

COCCI Neisseria meningitides: vaccination, penicillin G or ceftriaxone, rifampicin (prophylaxis) gonorrhoea: piperacillin-tazobactam 4.5g Q8hrly, ceftriaxone Moraxella azithromycin clarithromycin amoxicillin + clavulanate second or third generation cephalosporin co-trimoxazole 10mg/kg of sulphamethoxazole RODS/BACILLI -> aminoglycosides are good agents (gentamicin, tobramycin, amikacin, streptomycin)…

CCC Critical Care compendium 340
Antibacterial Resistance

Antibacterial Resistance: Natural Resistance – they do not possess the molecular target of the drug or are impermeable to it; Acquired resistance – occurs through mutation or the acquisition of new genetic material carried by mobile elements

CCC Critical Care compendium 340
Antimicrobial Stewardship

Antimicrobial Stewardship is defined as ‘an ongoing effort by a health-care institution to optimise antimicrobial use among hospital patients in order to improve patient outcomes, ensure cost-effective therapy and reduce adverse sequelae of antimicrobial use (including antimicrobial resistance)’