Protamine
CLASS
- neutralization of heparin
MECHANISM OF ACTION
- strongly basic protamine + strongly acid heparin -> forms stable salt -> removed by reticuloendothelial system.
- inhibits formation and activity of thromboplastin (extrinsic pathway)
PHARMACEUTICS
- purified mixture of low-molecular weight cationic proteins prepared from fish sperm (salmon).
- clear, colourless solution
- 10mg/mL
- protamine sulphate
DOSE
- 1mg protamine : 100u heparin
- reduce dose if more than 15 minutes has elapsed from heparin dose
INDICATIONS
- heparin reversal
- LMWH revesal
ADVERSE EFFECTS
- Hypotension
- Increased Pulmonary Vascular resistance
- Anaphylaxis
- Bleeding
- Bradycardia
PHARMACOKINETICS
- Absorption
- Distribution
- Metabolism – ?
- Elimination – t ½ = 60min
References and Links
|
CCC Transfusion Series |
|
|
Cryoprecipitate, Fresh Frozen Plasma (FFP), Platelets, Red Cells (RBCs) Concentrates: Prothrombinex, Factor VIIa, Fibrinogen Concentrate |
|
|
Reversal |
Rivaroxaban / Apixaban / Enoxaparin: Andexanet Alfa, Rivaroxaban and Bleeding Dabigatran: Idarucuzimab, Dabigatran and bleeding Warfarin: Vitamin K / FFP / PTx, Warfarin Reversal, Warfarin Toxicity |
|
Testing |
Coagulation Studies, TEG / ROTEM (Thromboelastography), Platelet function assays |
|
General Topics |
Acute Coagulopathy of Trauma, Blood Bank, Blood conservation strategies, Blood Product Compatibilities, Blood transfusion risks, Disseminated Intravascular Coagulation, Massive blood loss, Massive transfusion protocol (MTP), Modifications to blood components,Procedures and Coagulopathy, Storage Lesions, TRALI, Transfusion Literature Summaries, Transfusion Reactions |
References
Emergency Medicine PharmD — Protamine for LMWH (2013)
[cite]
Critical Care
Compendium
Chris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. He is also a Clinical Adjunct Associate Professor at Monash University. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. He is on the Board of Directors for the Intensive Care Foundation and is a First Part Examiner for the College of Intensive Care Medicine. He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives.
After finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. He has completed fellowship training in both intensive care medicine and emergency medicine, as well as post-graduate training in biochemistry, clinical toxicology, clinical epidemiology, and health professional education.
He is actively involved in in using translational simulation to improve patient care and the design of processes and systems at Alfred Health. He coordinates the Alfred ICU’s education and simulation programmes and runs the unit’s education website, INTENSIVE. He created the ‘Critically Ill Airway’ course and teaches on numerous courses around the world. He is one of the founders of the FOAM movement (Free Open-Access Medical education) and is co-creator of litfl.com, the RAGE podcast, the Resuscitology course, and the SMACC conference.
His one great achievement is being the father of three amazing children.
On Twitter, he is @precordialthump.
| INTENSIVE | RAGE | Resuscitology | SMACC